EVALUATION OF ANTICONVULSANT ACTION OF PROPOXAZEPAM ON PENTYLENETETRAZOLE-KINDLING MODEL OF SEIZURE IN MICE

EVALUATION OF ANTICONVULSANT ACTION OF PROPOXAZEPAM ON PENTYLENETETRAZOLE-KINDLING MODEL OF SEIZURE IN MICE

Дата публикации статьи в журнале: 18.12.2018
Название журнала: ASJ, Выпуск: № (22) / 2018, Том: 1, Страницы в выпуске: 58-63
Автор:
Odessa, V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Doctor of science (Biology), professor, Leading Researcher
Автор: Larionov Vitalii Borisovich
Odessa, V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, Doctor of science (Biology), Senior Researcher,
Автор: Reder Anatolii Semenovich
Odessa, V. Bogatsky Physico-Chemical Institute of NAS of Ukraine, PhD (Chemistry), Senior Researcher
Анотация:

Abstract
Kindling model of epilepsy on mice was induced by subcutaneous pentylenetetrazol (PTZ) injections (30 mg/kg)
each second-third day during 29 days. Experimental animals were treated with propoxazepam (0,2; 0,6; 1,0 and 2.0
mg/kg, intraperitonealy) 30 min prior to convulsive agent injection. Quantities of different seizures types (in accordance
to standard scale) were counted during 1 hour after PTZ injection. The highest quantity of minimal severity seizures (1
point) was registered at animals of control group from 3th to 8th and after 8th PTZ injections. Propoxazepam administration did not lead to reliable changes of seizures manifestations, but constrained second type seizures development,
reducing their quantity. The statistically significant redistribution in seizures quantity of second and fourth severity
types with simultaneous increasing of higher severity seizures was noted. At the same time seizures of fourth severity
type were diminished. For animals of control and experimental groups the reducing of first and second severity seizures
types latent time was noted. With propoxazepam administration reducing of higher severity seizures types (3th and 4nd
type) was in accordance with reducing of the latency time for seizures of 1th and 2nd types.

Ключевые слова: propoxazepam   pentylenetetrazol kindling epilepsy  antiepileptic effects  components of seizure              
DOI:
Данные для цитирования: Golovenko Nikolay Yakovlevich Larionov Vitalii Borisovich Reder Anatolii Semenovich. EVALUATION OF ANTICONVULSANT ACTION OF PROPOXAZEPAM ON PENTYLENETETRAZOLE-KINDLING MODEL OF SEIZURE IN MICE. ASJ. Медицинские науки. 18.12.2018; № (22) / 2018(1):58-63.

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