Дата публикации статьи в журнале: 2020/10/12
Название журнала: Американский Научный Журнал, Выпуск: 41, Том: 3, Страницы в выпуске: 8-10
Armenia , Yerevan State Medical University after M.Heratsy , Research Institute of Cardiology,
Анотация: Introduction: Atrial fibrillation (AF) is associated with prothrombotic or hypercoagulable states, various inflammation markers such as interleukin-6 (IL-6) and hsC-reactive protein (hsCRP) have also been associated with AF. The aim of this study is to investigate the relationship between inflammation markers and the prothrombotic state in the setting of AF and the impact on outcome in patients with AF.
Methods: We observed 141 patients with non-valvular AF. As a control group patients similar in gender and age without AF were examined. Clinical, instrumental and laboratory tests were performed on the observed patients. The markers of the coagulation cascade (TF and F) and of inflammatory markers (hsCRP and IL-6) were studied additionally by ELISA on the analyzer "Stat Fax 303 Plus". Studies were conducted using SPSS 13.0 and EXCEL-2013.
Results: The obtained results showed that compared to the control group, AF patients had significantly higher levels of IL-6 (p = 0.043), hsCRP (p = 0.002), TF (p = 0.026), and F (p = 0.025). Moreover, levels of hsCRP were higher among AF patients at "high" risk of stroke by CHA2DS2-VASc Score (p = 0.003). Besides, the levels of hsCRP and IL-6 were markedly elevated in patients with dilated left atrium (p = 0.001), poorly functioning left atrial appendage (p = 0.023) and longer duration of AF (p = 0.002).
Conclusion: We have demonstrated that the increased plasma levels of IL-6 and hsCRP are related to indices of the coagulation cascade and contribute to structural atrial remodeling in patients with AF.
Данные для цитирования: Hazarapetyan L.G. Grigoryan S.V. Sarksyan A.A. . THE ROLE OF INFLAMMATION AND COAGULATION CASCADE IN THE PATHOGENESIS OF ATRIAL FIBRILLATION (8-10). Американский Научный Журнал. Медицинские науки. 2020/10/12; 41(3):8-10. 10.31618/asj.2707-9864.2020.3.41.32
Список литературы: . Dernellis J, Panaretou M , Effect of C-reactive protein reduction on paroxysmal atrial fibrillation, Amer.Heart J. 2005, 4, 12-14.
. Grigoryan S.V., Adamyan K.G., Hazarapetyan L.G., Tumor necrosis factor as a prognostic marker of paroxysmal atrial fibrillation, ECAS Congress, Paris, France, April 19-21. 2009 Abstract 15-08.
. Maehama T, Okura H, Imai K et al., Systemic inflammation and left atrial thrombus in patients with non-rheumatic atrial fibrillation,J Cardiol. 2010,56, 118-124. http://dx.doi.org/10.1016/j.jjcc.2010.03.006.
. Harada M, Van Wagoner, D.R., Nattel S., Role of inflammation in atrial fibrillation pathophysiology and management, Circulation. 2015, 79(3), 495–502.
. You-Jung Choi, Eue-Keun Choi, Kyung-Do
Han et al., Increased risk of atrial fibrillation in patients with inflammatory bowel disease: A nationwide population-based study, World J Gastroenterol. 2019, 25(22), 2788-2798. doi: 10.3748/wjg.v25.i22.2788
. Sonmez, O, Ertem, F.U, Vatankulu M.A, Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation, Med Sci Monit. 2014, 20,463–470.
. Acevedo M., Corbalan R., Braun S. et al, Creactive protein and atrial fibrillation: evidence for the presence of inflammation in the perpetuation of the arrhythmia , Am J Cardiol. 2006,108 (3), 326-331
. Adamyan K.G., Grigoryan S.V.,
Hazarapetyan L.G., The role of latent inflammation in the pathogenesis of atrial fibrillation, Journal of Arrhythmology. 2008, 54, 34-41 [Publ. in Russian]
.Cianfrocca C, Loricchio M.L, Pelliccia F, et al, C-reactive protein and left atrial appendage velocity are independent determinants of the risk of thrombogenesis in patients with atrial fibrillation, Int J Cardiol. 2010,
. Hayashi M., Takeshita K, Inden Y.et al, Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: Involvement of mononuclear cell-platelet interaction K , Thrombosis Research. 2011, 126, 6, e113-e118.
. Jesel L, Arentz T .Herrera-Siklody Cl., Trenk D, et al, Do Atrial Differences in Endothelial Damage,
Leukocyte and Platelet Activation, or Tissue Factor Activity Contribute to Chamber-Specific Thrombogenic Status in Patients with Atrial Fibrillation?, Journal of Cardiovascular
Electrophysiology. 2014, 25, 3, 266–270.
. Reiffel J.A., Atrial fibrillation and stroke:
epidemiology, Am J Med. 2014, 127(4), e15–e16.
. Li YG, Lee SR, Choi EK, Lip GY, Stroke Prevention in Atrial Fibrillation: Focus on Asian Patients, Korean Circ J. 2018, 48,665-684.